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422 21st Street, Denver, CO – $1,250,000

  • 4 Beds
  • 2 Baths
  • 6,565 Sqft
  • .14 Acres
  • 4 Beds
  • 2 Baths
  • 6,565 Sqft
  • .14 Acres

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422 21st Street

Located in the heart of Five Points, this unique for-sale offering presents a compelling investment, owner-user, or redevelopment opportunity on a highly visible 6,270 SF corner lot just steps from Downtown Denver, Uptown, and the vibrant Five Points district. The property consists of a well-maintained single-family home and an adjacent office duplex, providing multiple income streams and flexible future potential. The approximately 2,565 SF single-family residence features four bedrooms and two bathrooms and is most recently operated as a successful Airbnb, offering immediate short-term rental income or the option for an owner-user residence. The office duplex is comprised of two office units of approximately 2,000 SF each, both tenant-occupied on month-to-month leases, allowing for steady income with near-term flexibility for repositioning or redevelopment. With its premier corner location, walkability to Denver’s central business district, and proximity to restaurants, nightlife, transit, and cultural amenities, this property offers exceptional upside in one of Denver’s most dynamic and rapidly evolving neighborhoods.

Listing Office: Kentwood Commercial, Llc

Essential Information

  • MLS® #6487194
  • Price$1,250,000
  • Bedrooms4
  • Bathrooms2.00
  • Full Baths1
  • Square Footage6,565
  • Acres0.14
  • Year Built1886
  • TypeResidential
  • Sub-TypeSingle Family Residence
  • StatusActive

Community Information

  • Address422 21st Street
  • SubdivisionFive Points
  • CityDenver
  • CountyDenver
  • StateCO
  • Zip Code80205

Interior

  • HeatingHot Water
  • CoolingNone
  • StoriesTwo

Exterior

  • Lot DescriptionLevel
  • RoofComposition

School Information

  • DistrictDenver 1
  • ElementaryWhittier E-8
  • MiddleCole Arts And Science Academy
  • HighEast

Additional Information

  • Date ListedFebruary 10th, 2026
  • ZoningC-MX-5

Listing Details

  • Kentwood Commercial, Llc
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Listing information last updated on February 13th, 2026 at 4:48pm MST.